• 2021 - Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C-C and C-O bonds
CALEFFI, GUILHERME S. ; BRUM, JULIANA DE O. C. ; COSTA, ANGELA T. ; DOMINGOS, JORGE L. O. ; COSTA, PAULO R. R.. JOURNAL OF ORGANIC CHEMISTRY, v. 86, p. 4849-4858, 2021.
• 2021 - New 5-carba-pterocarpans: Synthesis and preliminary antiproliferative activity on a panel of human cancer cells
GASPAR, FRANCISCO V. ; MARQUES RIBEIRO, SORAYA ; BARCELLOS, JÚLIO C.F. ; MONTEIRO, SAMUEL ; DOMINGOS, JORGE L.O. ; CLAUDIA DOS SANTOS LUCIANO, MARIA ; PAIER, CARLOS R.K. ; PESSOA, CLÁUDIA ; COSTA, PAULO R.R.. BIOORGANIC CHEMISTRY, v. 107, p. 104584, 2021.
• 2021 - Synthesis of new α-Aryl-α-tetralones and α-Fluoro-α-aryl-α-tetralones, preliminary antiproliferative evaluation on drug resistant cell lines and in silico prediction of ADMETox properties
DE SOUZA, LUANA G. ; Salustiano, Eduardo J. ; DA COSTA, KELLI M. ; COSTA, ANGELA T. ; Rumjanek, Vivian M. ; DOMINGOS, JORGE L.O. ; RENNÓ, MAGDALENA N. ; COSTA, PAULO R.R.. BIOORGANIC CHEMISTRY, v. 110, p. 104790, 2021.
• 2021 - The pterocarpanquinone LQB-118 compound induces apoptosis of cytarabine-resistant acute myeloid leukemia cells
HANCIO, THAÍS ; MAZZOCCOLI, LUCIANO ; GUIMARÃES, GUSTAVO ; ROBAINA, MARCELA ; MENDONÇA, BRUNA ; NESTAL DE MORAES, GABRIELA ; MONTE'MOR, BARBARA ; MAYUMI GUTIYAMA, LUCIANA ; DE CARVALHO, LUÍZE ; NETTO, CHAQUIP ; COSTA, PAULO ; DE FARIA, FERNANDA ; MAIA, RAQUEL.. INTERNATIONAL JOURNAL OF ONCOLOGY, v. 58, p. 24, 2021.
• 2021 - N - tert -Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles
MENDES, JOSEANE A ; COSTA, PAULO R R ; YUS, MIGUEL ; FOUBELO, FRANCISCO ; BUARQUE, CAMILLA D.. Beilstein Journal of Organic Chemistry, v. 17, p. 1096-1140, 2021.
• 2021 - The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi
MACEDO, CAROLINA MACHADO ; SARAIVA, FRANCIS MONIQUE DE SOUZA ; PAULA, JÉSSICA ISIS OLIVEIRA ; NASCIMENTO, SUELEN DE BRITO ; COSTA, DÉBORA DE SOUZA DOS SANTOS ; COSTA, PAULO ROBERTO RIBEIRO ; DIAS, AYRES GUIMARÃES ; PAES, MARCIA CRISTINA ; NOGUEIRA, NATÁLIA PEREIRA.. Frontiers in Microbiology, v. 12, p. 873, 2021.
• 2021 - Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity
PACHECO, JULIANA DA SILVA ; COSTA, DÉBORA DE SOUZA ; CUNHA-JÚNIOR, EDÉZIO FERREIRA ; ANDRADE-NETO, VALTER VIANA ; FAIRLAMB, ALAN H. ; WYLLIE, SUSAN ; GOULART, MARÍLIA O. F. ; SANTOS, DANYELLE C. ; SILVA, THAISSA L. ; ALVES, MARINA A. ; COSTA, PAULO R. R. ; DIAS, AYRES G. ; TORRES-SANTOS, EDUARDO CAIO.. ACS Medicinal Chemistry Letters, v. 12, p. 1405-1412, 2021.
2020
• 2020 - LQB-118 compound inhibits migration and induces cell death in glioblastoma cells
BERNARDO, PAULA ; GUIMAR'ES, GUSTAVO HENRIQUE ; DE FARIA, FERNANDA ; LONGO, GABRIEL ; LOPES, GISELLE ; NETTO, CHAQUIP ; COSTA, P.R.R. ; MAIA, R. C.. ONCOLOGY REPORTS, v. 43, p. 346-357, 2020.
• 2020 - The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro
LIMA, ÉSSIA DE ALMEIDA ; CAVALCANTE-SILVA, LUIZ HENRIQUE AGRA ; CARVALHO, DEYSE CRISTINA MADRUGA ; NETTO, CHAQUIP DAHER ; COSTA, PAULO ROBERTO RIBEIRO ; RODRIGUES-MASCARENHAS, SANDRA.. INTERNATIONAL IMMUNOPHARMACOLOGY, v. 83, p. 106399, 2020.
• 2020 - Theoretical studies and NMR assay of coumarins and neoflavanones derivatives as potential inhibitors of acetylcholinesterase
DE SOUZA, LUANA G. ; MORAES, PAULA F. ; LEÃO, RAQUEL A.C. ; COSTA, PAULO R.R. ; SOARES, ROSEMBERG O. ; PASCUTTI, PEDRO G. ; FIGUEROA-VILLAR, JOSE D. ; RENNÓ, MAGDALENA N.. COMPUTATIONAL BIOLOGY AND CHEMISTRY, v. 87, p. 107293, 2020.
• 2020 - Synthesis of pterocarpans through palladium-catalyzed oxyarylation of alkoxy-2H-chromenes with o-iodophenols
GASPAR, FRANCISCO V. ; BARCELLOS, JULIO C.F. ; CÍVICOS, JOSÉ F. ; MERINO, PEDRO ; NÁJERA, CARMEN ; COSTA, PAULO R.R.. TETRAHEDRON, v. 76, p. 131638, 2020.
2019
• 2019 - Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-Tumor Activity against MDR Leukemias
• 2019 - Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias
MENDES, JOSEANE A. ; MERINO, PEDRO ; SOLER, TATIANA ; Salustiano, Eduardo J. ; COSTA, PAULO R. R. ; YUS, MIGUEL ; FOUBELO, FRANCISCO ; Buarque, Camilla D.. JOURNAL OF ORGANIC CHEMISTRY, v. 84, p. 2219-2233, 2019.
• 2019 - Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms
STRAUCH, MARCELO A. ; TOMAZ, MARCELO AMORIM ; MONTEIRO-MACHADO, MARCOS ; CONS, BRUNO LEMOS ; PATRÃO-NETO, FERNANDO CHAGAS ; TEIXEIRA-CRUZ, JHONATHA DA MOTA ; TAVARES-HENRIQUES, MATHEUS DA SILVA ; NOGUEIRA-SOUZA, PÂMELLA DOURILA ; GOMES, SARA L. S. ; COSTA, PAULO R. R. ; SCHAEFFER, EDGAR ; DA SILVA, ALCIDES J. M. ; MELO, PAULO A.. PLoS One, v. 14, p. e0211229, 2019.
• 2019 - Enantioselective electrophilic fluorination of α-aryl-tetralones using a preparation of N-fluoroammonium salts of cinchonine
SOUZA, LUANA G. ; DE O. DOMINGOS, JORGE L. ; DE A. FERNANDES, TALITA ; RENNO, MAGDALENA N. ; SANSANO, JOSE M. ; NAJERA, CARMEN ; COSTA, PAULO R.R.. JOURNAL OF FLUORINE CHEMISTRY, v. 217, p. 72-79, 2019.
• 2019 - Switching Diastereoselectivity in Catalytic Enantioselective (3+2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos-Derived Ligands
CALEFFI, GUILHERME S. ; LARRAÑAGA, OLATZ ; FERRÁNDIZ-SAPERAS, MARCOS ; COSTA, PAULO R. R. ; NÁJERA, CARMEN ; DE CÓZAR, ABEL ; COSSÍO, FERNANDO P. ; SANSANO, JOSÉ M.. JOURNAL OF ORGANIC CHEMISTRY, v. 84, p. 10593-10605, 2019.
• 2019 - The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration
LEMOS, LAUANA GREICY TONON ; LONGO, GABRIEL MELLO DA CUNHA ; MENDONÇA, BRUNA DOS SANTOS ; ROBAINA, MARCELA CRISTINA ; BRUM, MARIANA CONCENTINO MENEZES ; CIRILO, CAÍQUE DE ASSIS ; GIMBA, ETEL RODRIGUES PEREIRA ; COSTA, PAULO ROBERTO RIBEIRO ; BUARQUE, CAMILLA DJENNE ; NESTAL DE MORAES, GABRIELA ; MAIA, RAQUEL CIUVALSCHI.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, p. 5063, 2019.
• 2019 - Snake venom activities as a tool to develop new metalloproteinase inhibitors from synthetic derivatives of lapachol
STRAUCH, MARCELO ABRAHÃO ; DE ASSIS MELO, PAULO ; MACHADO, MARCOS MONTEIRO ; PATRAO-NETO, FERNANDO CHAGAS ; NOGUEIRA-SOUZA, PAMELLA DOURILA ; DA MOTA TEIXEIRA-CRUZ, JHONATHA ; GOMES, SARA L.S. ; RIBEIRO COSTA, PAULO ROBERTO ; SCHAEFFER, EDGAR ; MONTEIRO DA SILVA, ALCIDES JOSE ; MELO, Paulo A.. TOXICON, v. 168, p. S32, 2019.
• 2019 - Medicinal Electrochemistry of Halogenated and Nitrated Pterocarpanquinones
SILVA, THAISSA ; DA SILVA, JULIO ; LIMA, DIMAS ; FERREIRA, FABRICIA ; DE VASCONCELOS, CAMILA ; SANTOS, DANYELLE ; NETTO, CHAQUIP ; COSTA, PAULO ; GOULART, MARÍLIA.. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 30, p. 2438-2451, 2019.
2018
• 2018 - The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
MARTINO, THIAGO ; KUDROLLI, TARANA A. ; KUMAR, BINOD ; SALVIANO, ISIS ; MENCALHA, ANDRÉ ; COELHO, MARSEN GARCIA P. ; JUSTO, GRAÇA ; COSTA, PAULO R. RIBEIRO ; SABINO, KÁTIA C. CARVALHO ; LUPOLD, SHAWN E.. PROSTATE, v. 78, p. 140-151, 2018.
• 2018 - Second-generation pterocarpanquinones: synthesis and antileishmanial activity
FAIÕES, VIVIANE DOS SANTOS ; DA FROTA, LÍVIA C. R. M. ; CUNHA-JUNIOR, EDÉZIO FERREIRA ; BARCELLOS, JULIO C. F. ; DA SILVA, THAYSSA ; NETTO, CHAQUIP DAHER ; DA-SILVA, SILVIA AMARAL GONÇALVES ; DA SILVA, ALCIDES J. M. ; COSTA, PAULO R. R. ; TORRES-SANTOS, EDUARDO CAIO.. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, v. 24, p. 35, 2018.
• 2018 - 11a- N -tosyl-5-carbapterocarpans: synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties
MENDES, JOSEANE A. ; Salustiano, E.J. ; PIRES, CARULINI DE S. ; OLIVEIRA, THAÍS ; BARCELLOS, JULIO C.F. ; CIFUENTES, JHONNY M.C. ; COSTA, P.R.R. ; RENNÓ, MAGDALENA N. ; Buarque, Camilla D.. BIOORGANIC CHEMISTRY, v. 80, p. 585-590, 2018.
• 2018 - New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations
LEÃO, RAQUEL A.C. ; PINHO, VAGNER D. ; COELHO, ARTUR S. ; KÜMMERLE, ARTHUR E. ; COSTA, PAULO R.R.. ANAIS DA ACADEMIA BRASILEIRA DE CIÊNCIAS, v. 90, p. 1273-1278, 2018.
2017
• 2017 - Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies
• 2017 - Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone LQB-118
SCATENA, GABRIEL S. ; CASSIANO, NEILA M. ; NETTO, CHAQUIP D. ; COSTA, PAULO R.R. ; CASS, QUEZIA B. ; BATISTA, JOÃO M.. CHIRALITY, v. 29, p. 167-171, 2017.
• 2017 - Solvent-Free Synthesis of Salen Ligands and Pd(II)- and Cu(II)-Salen Complexes: Their Use in the Oxidation of α-Tetralones to α-Naphthols
COSTA, PAULO; CÍVICOS, JOSÉ ; COIMBRA, JULIANA.. SYNTHESIS-STUTTGART, v. 49, p. A-1, 2017.
• 2017 - Palladium-Catalyzed α-Arylation of Dimethyl Malonate and Ethyl Cyanoacetate with o-Alkoxybromobenzenes for the Synthesis of Phenylacetic Acid, Esters and Phenylacetonitriles
CÍVICOS, JOSÉ ; COSTA, PAULO ; DOMINGOS, JORGE.. SynOpen, v. 01, p. 0091-0096, 2017.
• 2017 - Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative
CUPELLO, MAURICIO PEIXOTO ; SARAIVA, FRANCIS MONIQUE ; IPPOLITO, PEDRO ; FERNANDES, ANDRÉIA DA SILVA ; MENNA-BARRETO, RUBEM FIGUEIREDO SADOKO ; COSTA, DEBORA DE SOUSA DOS SANTOS ; PAULA, JESSICA ISIS OLIVEIRA ; COSTA, P.R.R. ; NOGUEIRA, NATÁLIA PEREIRA ; FELZENSWALB, ISRAEL ; DIAS, A. G. ; PAES, MARCIA CRISTINA.. Biomed Research International, v. 2017, p. 1-8, 2017.
2016
• 2016 - Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes
FERNANDES, TALITA DE A. ; VIZCAÍNO-MILLA, PASCUALA ; RAVASCO, JOÃO M.J.M. ; ORTEGA-MARTÍNEZ, AITOR ; SANSANO, JOSÉ M. ; NÁJERA, CARMEN ; COSTA, PAULO R.R. ; FISER, BÉLA ; GÓMEZ-BENGOA, ENRIQUE.. Tetrahedron: Asymmetry, v. 27, p. 118-122, 2016.
• 2016 - 5-Carba-pterocarpens: A New Scaffold with Anti-HCV Activity
FERNANDES, TALITA DE A. ; MANVAR, DINESH ; DOMINGOS, JORGE L.O. ; BASU, AMARTYA ; NICHOLS, DANIEL BRIAN ; KAUSHIK-BASU, NEERJA ; COSTA, PAULO R.R.. European Journal of Medicinal Chemistry, v. 112, p. 33-38, 2016.
• 2016 - Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis
CUNHA-JUNIOR, E. F. ; MARTINS, T. M. ; CANTO-CAVALHEIRO, M. M. ; MARQUES, P. R. ; PORTARI, E. A. ; COELHO, M. G. P. ; NETTO, C. D. ;COSTA, P.R.R. ; SABINO, K. C. C. ; TORRES-SANTOS, E. C.. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v. 60, p. 3794-3801, 2016.
• 2016 - Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis
ANDRADE-NETO, VALTER VIANA ; CUNHA-JÚNIOR, EDÉZIO FERREIRA ; CANTO-CAVALHEIRO, MARILENE MARCUZZO DO ; ATELLA, GEÓRGIA CORREA ; FERNANDES, TALITA DE ALMEIDA ; COSTA, PAULO ROBERTO RIBEIRO ; TORRES-SANTOS, EDUARDO CAIO.. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v. 60, p. 6844-6852, 2016.
• 2016 - In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118
SALUSTIANO, EDUARDO J. ; DUMAS, MATHEUS L. ; SILVA-SANTOS, GABRIEL G. ; NETTO, CHAQUIP D. ; COSTA, PAULO R. R. ; RUMJANEK, VIVIAN M.. INVESTIGATIONAL NEW DRUGS, v. 34, p. 541-551, 2016.
• 2016 - Reactive Oxygen Species Release, Alkylating Ability, and DNA Interactions of a Pterocarpanquinone: A Test Case for Electrochemistry
SILVA, THAISSA L. ; FERREIRA, FABRICIA R. ; DE'VASCONCELOS, CAMILA C. ; DA'SILVA, ROSANNY CHRISTHINNY ; LIMA, DIMAS JOSÉ DA P. ; COSTA, PAULO R. R. ; NETTO, CHAQUIP D. ; GOULART, MARÍLIA O. F.. ChemElectroChem, v. 3, p. 2252-2263, 2016.
• 2016 - Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice
RIÇA, INGRED G. ; NETTO, CHAQUIP D. ; RENNÓ, MAGDALENA N. ; ABREU, PAULA A. ; COSTA, PAULO R.R. ; DA SILVA, ALCIDES J.M. ; CAVALCANTE, MOISÉS C.M.. BIOORGANIC & MEDICINAL CHEMISTRY, v. 24, p. 4415-4423, 2016.
• 2016 - The syn-selective conjugate addition of amines to enoates derived from d-mannitol
BARCELLOS, JULIO C.F. ; VILELA, GUILHERME V.M. DE A. ; BORGES, BEATRIZ H.F. ; MIRANDA, MARIA F.F. ; DIAS, AYRES G. ; COSTA, PAULO R.R..TETRAHEDRON-ASYMMETRY, v. 27, p. 773-776, 2016.
• 2016 - Copper-versus palladium-catalyzed aromatization of 2-(methoxycarbonyl) tetralones: synthesis of methyl 1-hydroxy-2-naphthoates
CÍVICOS, JOSÉ F. ; ROCHA, CARLOS M. ; COSTA, PAULO R.R. ; NÁJERA, CARMEN.. TETRAHEDRON, v. 72, p. 1897-1902, 2016.
• 2016 - Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery
ALVES, M. A. ; NIRMA, C. ; MOREIRA, M. M. ; SOARES, R. O. ; PASCUTTI, P. G. ; NOËL, F. ; COSTA, P. R. R. ; SANT'ANNA, C. M. R. ; Barreiro, E. J. ; LIMA, L. M. ; TINOCO, L. W.. RSC Advances, v. 6, p. 87738-87744, 2016.
2015
• 2015 - Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors
Manvar, Dinesh ; Fernandes, Talita De A. ; Domingos, Jorge L.O. ; Baljinnyam, Erdenechimeg ; Basu, Amartya ; Junior, Eurides F.T. ; COSTA, PAULO R.R. ; Kaushik-Basu, Neerja. European Journal of Medicinal Chemistry, v. 93, p. 51-54, 2015.
• 2015 - NFκB Pathway and microRNA-9 and -21 are Involved in Sensitivity to the Pterocarpanquinone LQB-118 in Different CML Cell Lines
• 2015 - Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues
Buarque, Camilla ; Domingos, Jorge ; Netto, Chaquip ; COSTA, PAULO. Current Organic Synthesis, v. 12, p. 772-794, 2015.
• 2015 - Abstract A51: Antineoplastic activity of novel synthetic compound pterocarpanquinone LQB-118 in lung cancer cells
Silva, Karina Lani ; Souza, Paloma Silva De ; COSTA, PAULO R.R. ; Maia, Raquel Ciuvalschi. Clinical Cancer Research, v. 21, p. A51-A51, 2015.
• 2015 - Abstract A49: Efficiency of 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) in a panel of myeloid leukemia cell lines with different chemoresistance backgrounds
Reis, Flaviana Ruade De Souza ; Mororó, Janio Da Silva ; Silva, Karina Lani ; Buarque, Camila D. ; COSTA, PAULO R.R. ; Maia, Raquel Ciuvalschi. Clinical Cancer Research, v. 21, p. A49-A49, 2015
• 2015 - Synthesis of N-methylarylnitrones derived from alkyloxybenzaldehydes and antineoplastic effect on human cancer cell lines
Costa, Débora S.S. ; Martino, Thiago ; Magalhães, Fernanda C. ; Justo, Graça ; Coelho, Marsen G.P. ; Barcellos, Julio C.F. ; Moura, Victor B. ; COSTA, PAULO R.R. ; Sabino, Kátia C.C. ; Dias, Ayres G. . Bioorganic & Medicinal Chemistry, v. 23, p. 2053-2061, 2015.
• 2015 - Synthesis of Chromen[4,3- b ]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol
COSTA, PAULO R. R. ; Sansano, José M. ; Cossío, Unai ; Barcellos, Julio C. F. ; Dias, Ayres G. ; Nájera, Carmen ; Arrieta, Ana ; De Cózar, Abel ; Cossío, Fernando P. . European Journal of Organic Chemistry, v. 2015, p. 4689-4698, 2015.
• 2015 - Synthesis of 11a-N-Arylsulfonyl-5-carbapterocarpans (Tetrahydro-5H-benzo[a]carbazoles) by Azaarylation of Dihydronaphthalenes with o-Iodo-N-(Arylsulfonyl)anilines in Poly(ethylene glycol)
Buarque, Camilla ; COSTA, PAULO ; Dias, Ayres ; Barcellos, Julio ; Borges, Beatriz ; Mendes, Joseane ; Ceron, Mauricio. Synthesis (Stuttgart), v. 47, p. 3013-3019, 2015.
• 2015 - Ligand-Free Palladium-Catalyzed Oxyarylation of Dihydronaphthalenes and Chromenequinone with o-Iodophenols and 3-Iodolawsone in PEG-400: An Efficient Synthesis of 5-Carbapterocarpans and Pterocarpanquinones
COSTA, PAULO ; De Moraes, Paula ; Gaspar, Francisco ; Borges, Rackel ; Netto, Chaquip ; Leão, Raquel ; Nájera, Carmen. Synthesis (Stuttgart), v. 47, p. 3505-3512, 2015.
• 2015 - Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro
Da Silva, Luciana Lemos Rangel ; Portes, Juliana De Araujo ; De Araújo, Marlon Heggdorne ; Sant'ana Silva, Jéssica Lays ; Rennó, Magdalena Nascimento ; Netto, Chaquip Daher ; Da Silva, Alcides José Monteiro ; COSTA, PAULO ROBERTO RIBEIRO ; De Souza, Wanderley ; Seabra, Sergio Henrique ; Damatta, Renato Augusto. Parasitology International, v. 64, p. 622-631, 2015.
2014
• 2014 - Synthesis of 5-Carbapterocarpens by α-Arylation of Tetralones Followed by One-Pot Demethylation/Cyclization with BBr 3
Fernandes, Talita de A. ; Domingos, Jorge l. O. ; Da Rocha, Luiza I. A. ; de Medeiros, Sabrina ; Nájera, Carmen COSTA, PAULO R. R. .European Journal of Organic Chemistry, v. 2014, p. 1314-1320, 2014.
• 2014 - 11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines.
Buarque, Camilla D. ; Salustiano, Eduardo J. ; Fraga, Kevin C. ; Alves, Bruna R.M. ; COSTA, PAULO R.R. . European Journal of Medicinal Chemistry, v. 78, p. 190-197, 2014.
• 2014 - The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors
Nestal De Moraes, Gabriela ; Castro, Carolina ; Salustiano, Eduardo ; Dumas, Matheus ; Costas, Fernanda ; Lam, Eric ; COSTA, PAULO ; Maia, Raquel. .International Journal of Oncology, v. 45, p. 1949-1958, 2014.
• 2014 - Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum
Cortopassi, Wilian A. ; Penna-Coutinho, Julia ; Aguiar, Anna C. C. ; Pimentel, André S. ; Buarque, Camilla D. ; COSTA, PAULO R. R. ; Alves, Bruna R. M. ; França, Tanos C. C. ; Krettli, Antoniana U. .Plos One, v. 9, p. e91191, 2014.
• 2014 - The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression
Martino, Thiago ; Magalhães, Fernanda C.J. ; Justo, Graça A. ; Coelho, Marsen G.P. ; Netto, Chaquip D. ; COSTA, PAULO R.R. ; Sabino, Kátia C.C. .Bioorganic & Medicinal Chemistry, v. 22, p. 3115-3122, 2014.
• 2014 - Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters
Costa, Luciana ; Pinheiro, Roberta O. ; Dutra, Patrícia M. L. ; Santos, Rosiane F. ; Cunha-Júnior, Edézio F. ; Torres-Santos, Eduardo C. ; Da Silva, Alcides J. M. ; COSTA, PAULO R. R. ; Da-Silva, Silvia A. G. .Plos One, v. 9, p. e109672, 2014.
2013
• 2013 - The pterocarpanquinone LQB induces apoptosis in tumor cells through the intrinsic pathway and endoplasmic reticulum stress pathway
Bacelar, T. S. ; da Silva, A. J. M. ; COSTA, P.R.R. ; Rumjanek, V. M. Anti-Cancer Drugs, v. 3, p. 5-11, 2013.
• 2013 - LQB-118, an Orally Active Pterocarpanquinone, Induces Selective Oxidative Stress and Apoptosis in Leishmania Amazonensis.
Ribeiro, G. A Cunha-Júnior, E. F. ; Pinheiro, R. O. ; Silva, S. A. G. ; do Canto-Cavalheiro, M. M. ; da Silva, A. J. M. COSTA, P.R.R. Netto, C.D.; Melo, R. C. N. ; Almeida-Amaral, E. E. ;Torres-Santos, E. C. Journal of Antimicrobial Chemotherapy, v. 68, p. 789-799, 2013.
• 2013 - Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.
Nichols, Daniel B. ; Leão, Raquel A. C. ; Basu, Amartya ; Chudayeu, Maksim ; de Moraes, Paula de F. ; Talele, Tanaji T. ; COSTA, PAULO R. R. ; Kaushik-Basu, Neerja. Chemical Biology Drug design, v. 81, p. 607-614, 2013.
• 2013 - Palladium-Catalyzed Arylation of Enoates with Iodobenzene: Stereoselective Synthesis of Trisubstituted Olefins.
Fernandes, Talita de A. ; Vaz, Boniek G. ; Silva, Alcides J. M. da ; Esteves, Pierre M. ; Eberlin, Marcos N. ;COSTA, PAULO R. R.Journal of the Brazilian Chemical Society, v. 24, p. 500-506, 2013.
• 2013 - The Therapeutical Potential of a Novel Pterocarpanquinone LQB-118 to Target Inhibitor of Apoptosis Proteins in Acute Myeloid Leukemia Cells
Reis, F. R. S. ; Faria, F C C ; Souza, P. S. ; Vasconcelos, F. C. ; Castro, C. P. ; Bello, R. D. ; Silva, A. J. ;COSTA, P.R.R. ; Maia, R. C. Anti-cancer agents in Medicinal Chemistry, v. 13, p. 341-351, 2013.
2012
• 2012 - Purification of a synthetic pterocarpanquinone by countercurrent chromatography
Costa, F. N. ; da Silva, A. J. M. ; Netto, C.D. ; Domingos, J.L.O. ; COSTA, P.R.R. ; Leitão, G. G; Journal of the Brazilian Chemical Society, v. 23, p. 1114-1118, 2012.
• 2012 - A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro.
Portes, J. A. ; Netto, C.D. ; da Silva, A. J. M. ; COSTA, P.R.R. ; daMatta, R. A. ; dos Santos, T. A T. ; Souza, W. ; Seabra, S. H; Veterinary Parasitology, v. 186, p. 261-269, 2012.
2011
• 2011 - Microwave-Promoted Palladium-Catalysed Oxyarylation of Dihydronaphthalene and Chromenes by o-Iodophenols and Its Acetates.
Leão, R.A.C.; Pinho, V.D.; Coelho, A.S.; Buarque, C.D.; Moraes, P.F. ; Alonso, D.A.; Nájera, C ; Costa, P.R.R. European Journal of Organic Chemistry, 2011, 3313-3316, 2011
• 2011 - LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
Maia, R.C.; Vasconcellos, F.C.; Bacelar, T.S.; Salustiano, E.J.; da Silva, L.F.R.; Pereira, D.L.; Coelho, A.M.; Netto, C.D.; da Silva, A.J.M.; Rumjanek, V.M.; Costa, P.R.R.Investigational New Drugs, Vol 29, p. 1143-1155, 2011
• 2011 - Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis.
Cunha-Júnior, E. F. ; Pacienza-Lima, W. ; Ribeiro, G. A. ; Netto, C.D. ; do Canto-Cavalheiro, M. M. ; da Silva, A. J. M. ; COSTA, P.R.R. ; Rossi-Bergman, B. ; Torres-Santos, E. C. Journal of Antimicrobial Chemotherapy, v. 66, p. 1555-1559, 2011
• 2011 - Synthesis of Coumarins Through Zinc Chloride-Catalyzed Hydroarylation of Ethyl Propiolate by Phenols.
Leão, R. A. C. ; Moraes, P.F. ; Pedro, M. C. B. C. ; COSTA, P.R.R. ; Synthesis (Stuttgart), v. 22, p. 3692-3696, 2011.
• 2011 - Pterocarpanquinones, Aza-pterocarpanquinone and Derivatives: Synthesis, Antineoplasic Activity on Human Malignant Cell Lines and Antileishmanial Activity on Leishmania amazonensis
Buarque, C. D. ; Militão, G. C. G. ; Lima, D. J. B. ; Costa-Lotufo, L. V. ; Pessoa, C. O. ; Moraes, M. O. ; Cunha-Júnior, E. F. ; Torres-Santos, E. C. ; Netto, C.D. ; COSTA, P.R.R. ; Bioorganic ; Medicinal Chemistry (Print), v. 19, p. 6885-6891, 2011.
2010
• 2010 - Palladium-Catalyzed Tandem Heck-Lactonization from o-Iodophenols and Enoates: Synthesis of Coumarins and the Study of the Mechanism by Electrospray Ionization Mass Spectrometry
Fernandes, T.A.; Vaz, B.G.; Eberlin, M.N.; da Silva A. J. M.; Costa, PRRJournal of Organic Chemistry, 21, 7085-7091
• 2010 - A New and Concise Strategy to the Enantioselective Synthesis of (S)-2-Amino-4-Oxo-4-(Pyridine-2-yl) Butanoic Acid from Aspartic Acid
de Lima, EC; de Lima, PG; de Souza, CC; Maior, MCLS; Dias, AG; Costa, PRR Journal of The Brazilian Chemical Society, 21, 777-781
• 2010 - Ability of a synthetic coumestan to antagonize Bothrops snake venom activities.
• 2010 - New pterocarpanquinones: synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-alpha modulation in human PBMC cells.
• 2010 - Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry
• 2009 - Antitumoral, Antileishmanial and Antimalarial Activity of Pentacyclic 1,4-Naphthoquinone Derivatives
da Silva, AJM; Netto, CD; Pacienza-Lima, W; Torres-Santos, EC; Rossi-Bergmann, B; Maurel, S; Valentin, A; Costa, PRRJournal of the Brazilian Chemical Society, 20, 176-182
• 2009 - Inhibition of the a1b1 Isoform of the Na, K-ATPase by 8-Methoxycoumestrol without Positive Inotropic Effect in Human Myocardium - Novel Aspects of Cardiac Glycoside Pharmacology
• 2009 - Iodination of Phenols in Water Using Easy to Handle Amine-Iodine Complexes
da Frota, LCRM; Canavez, RCP; Gomes, SLD; Costa, PRR; da Silva, AJM Journal of the Brazilian Chemical Society, 20, 1916-1920
• 2009 - N-tert-Butyl and N-Methyl Nitrones Derived from Aromatic Aldehydes Inhibit Macromolecular Permeability Increase Induced by Ischemia/Reperfusion in Hamsters.
• 2008 - A tandem palladium-catalyzed Heck-lactonization through the reaction of ortho-iodophenols with b-substituted acrylates:synthesis of 4,6-substituted coumarins
• 2008 The reaction between phenylnitromethanes and enoate derived from D-mannitol in the presence of TBAF or DBU. Tandem SYN-selective conjugate addition and Nef reaction
• 2006 - Structure-Activity Relationship in Wedelolactone Analogues: Structural Requirements for Inhibition of Na+/K+-ATPase and Binding to the Central Benzodiazepine Receptor.
• 2004 - Crude D-(+)-glyceraldehyde obtained from D-mannitol-diacetonide by oxidative cleavage with sodium periodate: Its reactions with nucleophilic species.
• 2001 - Reaction of safrole derivatives with aluminum chloride: improved procedures for the preparation of catechols or their mono-o-methylated derivatives and a mechanistic interpretation
• 2001 A practical and efficient preparation of (-)-(4aS,5R)-4,4a,5,6,7,8-hexahydro-4a,5-dimethyl-2(3H)-naphthalenone: a key intermediate in the synthesis of (-)-dehydrofukinone
• 1997 - Asymmetric Friedel-Crafts Reactio Mediated by New Chiral Auxiliaries Derived From (1S)-(-)-(b)-Pinene: Enantioselective Synthesis of (-)-8-Norethyl, 1'-Normethyl Etodolac.
• 1997 - Stereocontrolled Elaboration of Quaternary Carbon Centers Involving the Asymmetric Michael-type Alkylation of Chiral Imines: an Efficient Enantioselective Access to (+)-Vincamine.
• 1991 - Asymmetric Michael addition of chiral imines to phenylvinylsulphone: Preparation of key chiral building blocks for the synthesis of Aspidosperma and Hunteria alkaloids.
• 1991 - Piperonal as starting material for the regioespecific and stereoselective synthesis of E and Z isomers of 3-methyl-2-hexenedioic acid-1-methyl ester.
• 1987 - Expeditious, stereocontrolled synthesis of racemic and natural brasilenol through intramolecular symetry transfer. Absolute stereochemistry of brasilenol.
• 1984 - Prostaglandin analogues: The synthesis of new prostaglandins from natural safrole.
Farias, FMC.; Barreiro, EJ; Coelho, FAS.; Costa, PRR Anais da Academia Brasileira de Ciências, 7, 111-112
• 1984 - Prostaglandin analogues: the synthesis of new tromboxaxane derivatives from natural safrole.
Coelho, FAS.; Farias, FMC.; Barreiro, EJ; Costa, PRR Anais da Academia Brasileira de Ciências, 7 113-115
• 1984 - The nature of solvent effects in the reaction of safrole with bromine
Costa, PRR.; Rabi, JA J Chem Researsch, 20-21
• 1984 - The reaction of safrole with brominating agents. Differential trapping of the intermediates by bromide and water.
Costa, PRR; Rabi, JA Journal of the Brazilian Chemical Society, 22-23
1983
• 1983 - A convenient method for the preparation of 6,7-methylenedio-xy-3-alkyl-2-hydroxy-1,4-naphthoquinones from natural safrole and carboxylic acids.
• 1983 - Eergia da ponte de hidrogênio entre moléculas S-trans na N-metil-formamida: cálculos pelo método CNDO/.
Costa, PRR.; Antunes, OAC.; Alencastro, RB Anais da Academia Brasileira de Ciências
• 1983 - Interaction of a nitro-group with adjacent cationic species to form nitronic lactones.
Costa, PRR; Rabi, JA Journal of Chemical Research. Synopses, 1, 201-216
1982
• 1982 - An improved synthesis from natural safrole of indole related to indomethacin.
Barros, PRVR; Barreiro, EJ; Queiroz, WM.; Costa, P.R.R Journal of Chemical Research , E U A, 1142-1165
• 1982 - Preparação de aldeídos fenilacéticos oxigenados pela reação de ozonólise de alilbenzenos naturais - Utilização do homopiperonal como precursor de unidades C6-C2.
Lopes, CC; Costa, PRR Anais da Academia Brasileira de Ciências, 54, 758-759
• 1982 - Síntese de derivados do ácido 2,3-indoil-acético a partir do safrol.